We should be making decisions now based on the evidence on the table today. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. Theres nothing there.). Dosage there is 30mg once a day. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). [NIH] doesnt want any of these treatments. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. It could do nothing. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. This is what the Seftel trial at Golden Gate fields used. See more below. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. Its all about NIH saying it is OK. . Note that some of these articles are inaccurate. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Talking to Kirsch is an exhausting experience. For decades, coders wrote critical systems in C and C++. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. Where did it go wrong. There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. saying that the per-protocol analysis was arbitrary and other excuses. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. In September, he resigned as CEO and gave up his board seat. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. All the supporting observational studies were positive as well. Thats what creates some of these heroes.. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. If you take fluvoxamine, please avoid caffeine while on the drug. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. We asked Steve to tone it down. Proxalutamide and fluvoxamine pushers and the early treatment grift. Compulsive hand washing? Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. Theyre finding alternative leaders to follow, Morris said. Hes now outlived his initial prognosis by several years. Personal life. Quick Summary . Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. The study was also featured on 60 Minutes. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. Consider masks by contrast. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. The. My favorite dosage is 50mg twice a day for 14 days. are all super cheap, effective, and available without a prescription. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. There are 4 outpatient studies that have been done (2 at WashU (see. 707. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. He started 7 high tech companies, two with billion dollar market caps. Both of them encouraged anyone reading this article to get vaccinated. The web price charge of skirsch.io . The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. and increased heart rate (which could be nerves about the dilated pupils). I fixed the link to the fluvoxamine article. But even that didnt last long. That covers almost 150,000 of them, which happened before vaccinations began. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. . S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. But even she was drained by Kirschs constant attempts to override the data. JAMA systematic review and meta analysis It doesnt get any better than this. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. So you can address your OCD and if you get COVID, youll can up the dose. But the potential upsides. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Fluvoxamine public data repository - Google Drive, On Cytokines, Fluvoxamine and COVID-19 Part 1, Jon-Emile S. Kenny MD[@heart_lung] You see, we have a kind of allergy to the past; its our national disease, and the very assurance with which you insist that the past is within the present is l, On Cytokines, Fluvoxamine and COVID-19 Part 2, Jon-Emile S. Kenny MD[@heart_lung] Apocalypse is played out now on a personal scale; it is not in the sky above us, but in our bed. -Mark Doty Introduction With a proposed pathway coupling patho, Effect of Fluvoxamine vs Placebo on Clinical Deterioration in Outpatients With Symptomatic COVID-19, This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reactionconfirmed mild coronavirus disease 2019 (, Prospective cohort of fluvoxamine for early treatment of COVID-19, Abstract. The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Share this post. Here is the latest version. Long haul. Once the Phase 2 result came out, it should have been embraced by doctors. Doctors who have used fluvoxamine in the US and other countries swear by it. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Medicine isnt about saving lives anymore. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. YouTube , , , fluvoxamine, , , , , , , , , , Over the summer, the conflict reached his most recent startup, M10. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. I must admit that this is an anniversary that snuck Government agencies are ignoring the science. Here are my answers. Some speaker, off camera, went on a . Fluoxetine is just as effective. Hes a genuinely good guy. Those who know Kirsch say this is a typical tactic. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients.